Wayne State University;Duquesne University of the Holy Spirit
发明人:
Aleem Gangjee,Larry H. Matherly
申请号：
US15342359
公开号：
US10000498B2
申请日:
2016.11.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I:These compounds are useful in methods for treating cancer, selectively targeting cancerous cells via the proton coupled folate transporter, folate receptor alpha, and/or folate receptor beta pathways, inhibiting GARFTase in cancerous cells, and selectively targeting activated macrophages in a patient having an autoimmune disease, such as rheumatoid arthritis.
