VENSKUS DITE,KALVINS IVARS,PJANOVA DACE,PETROVSKA Ramona,AUZINS JURGIS
申请号：
IN201627005191
公开号：
IN201627005191A
申请日:
2016.02.15
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
In a method for manufacturing a modified enterovirus of ECHO 7 type by modification of native ECHO 7 virus isolated by a known method from human feces and identified by genome sequence the modification is performed initially conducting the virus adaptation in cancer cells attenuated by anti cancer agent dacarbazine further passaging the modified virus in human embryonal fibroblast culture followed by propagation in human melanoma cells and further passaging in human embryonal fibroblast culture that was treated by ribavirin isolation and purification by known method. The modified virus is suitable for treating various tumours.
