A Pharmaceutical composition or nasal topical ophthalmic, OTIC antimicrobial comprising an effective amount of one or more compounds of the formula (1) where a is CH, CF, ITC, c or N X1 - OCH3, h,Halogen CH3, NH2 or C1 3 r1 is alkyl or phenyl, fch2ch2, ciclopropilo,Optionally, mono -, di - or tri substituted by Halogen or R1 and together they can form a Bridge formula CH2 - C - or - ch (CH3): R2 is H, alkyl, optionally substituted C1 3 (Oh, halogen,O5 or NH2) - methyl - 2 - oxo - 1.3 - dioxol-4-yl - Methyl and B is selected from the group consisting of formulas (2) and or alkoxyl or CH2 R3 is C2 - C5, co - CH2 - C6H5, ch2ch2co2r, ro2c - ch = C - CO2R,CH = CH - cor2r or ch2ch2cn where R1 is H or c1-3 alkyl R4 is H, alkyl, alkoxyl C1 - C3, C2 - C5 CH2 - CO - C6H5, ch2ch2co2r, ro2c C - - ch = CH - ch - CO2R CO2R or ch2ch2cn, or 5 - methyl - 2 - oxo - 1,4il - methyl - 3 - dioxol where R1 is alkyl or H: C1 - 3 and their carbohydrate and salesfarmac\u00e9uticamente useful and a vehicle farmac\u00e9uticamenteaceptable for them and the use of the same for ManufacturingA Medicine.Una composicion farmacéutica topica oftálmica, otica o nasal que comprende una cantidad efectiva antimicrobiana de uno o más compuestos de la formula (1)donde A es CH, CF, CCI, C-OCH3, o N X1 es H, halogeno, NH2 o CH3 R1 es alquilo C1 a 3,FCH2CH2, ciclopropilo o fenilo, opcionalmente mono-di- o tri-sustituido por halogeno o A y R1 juntos pueden formar un puente de formula C-O-CH2-CH(CH3): R2 es H, alquilo C1 a 3 (opcionalmente sustituido por OH, halogeno,o NH2) o5-metil-2-oxo-1,3-dioxol-4-il -metilo y B es seleccionado del grupo formado por las formulas (2) donde Y es O o CH2 R3 es alcoxilo C2-C5, CH2-CO-C6H5, CH2CH2CO2R, RO2C-CH=C-CO2R, CH=CH-COR2R o CH2CH2CN,donde R1 es H o alquilo C1-3, R4 es H,alquilo C1- C3, alcoxilo C2-C5 CH2 - CO-C6H5,CH2CH2CO2R, RO2C-CH=C-CO2R CH-CH-CO2R o CH2CH2CN, o 5-metil-2-oxo-1,3-dioxol-4il-metilo donde: R1 es H o alquilo C1-3 y sus hidratos y salesfarmacéuticamente ut
