PURIFICATION OF IDURONATE-2-SULFATASE

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专利权人:

INC.;SHIRE HUMAN GENETIC THERAPIES

发明人:

NICHOLS, Dave

申请号：

PH12015502408

公开号：

PH12015502408A1

申请日:

2015.10.16

申请国别(地区):

PH

年份:

2018

代理人:

摘要：

The present invention provides, among other things, improved methods for purifying 12 S protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant I2S protein can be purified from unprocessed biological materials, such as, I2S-containing cell culture medium, using a process involving as few as four chromatography columns.

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中国工程科技知识中心

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