GREEN, BRIAN MICHAEL,GRADLEY, MICHELLE LORRAINE,ALCASABAS, ANNETTE
申请号：
CA3015081
公开号：
CA3015081A1
申请日:
2017.02.28
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.
