The composition for describing a kind of method of the pharmaceutical composition of carrier of oxygen (HBOC) containing base what hemoglobin for preparing suitable what oral delivery and being consequently formed. There are three types of exemplary compositions to construct comprising (1) loads the nano-particle solution of hemoglobin, (2) enteric-coated hemoglobin capsule and (3) enteric-coated hemoglobin tablet. In order to promote the bioavilability and biocompatibility of hemoglobin, intestinal absorption enhancers are added in every kind of HBOC preparation. Protective layer ensures that complete hemoglobin construct delivers in enteron aisle without degrading under one's belt. The HBOC preparation can include blood loss, anaemia, the cancerous tissue of hypoxemia and other anoxic illnesss with what prevention or immediate treatment high mountain disease (HAS) or with what treatment hypoxemia illness. Other than delivering oxygen, the heme group of the hemoglobin from HBOC preparation can provide heme iron to human body to assist generating more red blood cells.描述了一種製備適合於口服遞送的含有基於血紅蛋白的氧載體(HBOC)的藥物組合物的方法以及由此形成的組合物。有三種示例性組合物構造，其包括(1)負載血紅蛋白的納米粒子溶液，(2)包有腸溶衣的血紅蛋白膠囊和(3)包有腸溶衣的血紅蛋白片劑。爲了促進血紅蛋白的生物利用度和生物相容性，在每種HBOC製劑中添加腸吸收促進劑。保護層確保完整血紅蛋白結構在腸道中遞送而不會在胃中降解。所述HBOC製劑可以用於預防或即刻治療高山症(HAS)或用於治療低氧病症包括失血、貧血、低氧的癌組織、和其他缺氧病症。除了遞送氧以外，來自HBOC製劑的血紅蛋白的血紅素基團可以向人體提供血紅素鐵以輔助産生更多的紅細胞。
