Stefan G. KOENIG;H. Scott WILKINSON;Charles P. VANDENBOSSCHE;Hang ZHAO;Surendra SINGH;Roger P. BAKALE
发明人:
Hang ZHAO,Stefan G. KOENIG,Charles P. VANDENBOSSCHE,Surendra SINGH,H. Scott WILKINSON,Roger P. BAKALE
申请号：
US13333616
公开号：
US20120095106A1
申请日:
2011.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
