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MEDICINAL USE OF ALPHA-MANNOSIDASE
专利权人:
Chiesi Farmaceutici S.p.A.
发明人:
ANDERSSON, CLAES,FOGH, JENS,WEIGELT, CECILIA,ROCES, DIEGO PRIETO,VON FIGURA, KURT,IRANI, MEHER
申请号:
PL05715146
公开号:
PL1740204T3
申请日:
2005.04.01
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
The present invention provides means and strategies for treating the lysosomal storage disorder alpha-mannosidosis by enzyme replacement therapy. In particular, the invention pertains to the reduction of stored neutral mannose-rich oligosaccharides in cells within the central nervous system. Accordingly, the present invention provides the use of a lysosomal alpha-mannosidase for the preparation of a medicament for reducing the intracellular levels of neutral mannose-rich oligosaccharides in cells within one or more regions of the central nervous system. The invention further provides a formulation of lysosomal alpha-mannosidase for use as a medicament for reducing the intracellular levels of neutral mannose-rich oligosaccharides in cells within one or more regions of the central nervous system. Also, the invention provides a method of reducing the intracellular levels of neutral mannose-rich oligosaccharides in cells within one or more regions of the central nervous system of a subject, said method comprising administering to said subject a preparation of lysosomal alpha-mannosidase. Finally, the invention pertains to methods of producing, isolating, and purifying an alpha-mannosidase as well as the use of an alpha-mannosidase, which is obtainable according to these methods.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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