CHAMBERLAIN, AARON,DAHIYAT, BASSIL,DESJARLAIS, JOHN RUDOLPH,KARKI, SHER BAHADUR
申请号：
CA2703385
公开号：
CA2703385C
申请日:
2008.09.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present application relates to optimized IgG immunoglobulin variants,engineering methods for their generation and their application. Specificallythepresent invention relates to a polypeptide comprising an Fc variant of a humanIgGFc polypeptide. The Fc variant comprises, according to Kabat numbering, anisoleucine at position 259 and a phenylalanine at position 308, and showsincreasedbinding to human FcRn as compared to said human IgG Fc polypeptide.
