Адам Жан-Мішель,Біссанц Катерина,Гретер Уве,Кімбара Ацусі,Неттекофен Маттіас,Рьофер Штефан,Роджерс-Еванс Марк
申请号：
UAA201406094
公开号：
UA111640C2
申请日:
2012.11.05
申请国别(地区):
UA
年份:
2016
代理人:
摘要：
Claim 1: a compound of the formula (1) in which a is hidroxialquilo, ch u2082c alkyl - (o) -, - C (o) -, - or - SO u2082 is absent； r u00b9 is Hydrogen, alkyl, alkoxy, haloalquilo, hydroxyl, haloalcoxi, phenyl, halofenilo, alcoxifenilo, haloalquilfenilo, haloalcoxifenilo (Halo), F (haloalquil) Enilo, cianofenilo, hidroxialcoxifenilo, alquilsulfonilfenilo, alquilsulfonilaminofenilo, cyano, cycloalkyl,Cicloalquilalcoxi, amino, (alquilsulfonil) (alkyl) [1,2,4] Tri azolilo (Halo) (dialquilamino pyridinyl) (alkyl) (Oxy) pyridinyl, nitro - benzo [1,2,5] oxadiazolilaminopiridinilo, heterociclilo, alquilheterociclilo, hidroxiheterociclilo, alquilheterociclilo, heteroaryl, haloheteroarilo, alquilheteroaril Or, cicloalquilheteroarilo or haloalquilheteroarilo,This is a heterociclilo Ring carboc u00edclico three to eight Member contains at least one nitrogen Atom or Oxygen, and this is pirazolilo, pyridinyl heteroaryl, oxadiazolilo, furazanilo, tetrazolilo R u00b2 is Halogen, or triazolilo；- nr u00b3r u2074 or - or u2075； one of r u00b3 and r u2074 is Hydrogen or alkyl, and the other is alkyl or cycloalkyl or r u00b3 and r u2074； along with the nitrogen Atom to form a United heterociclilo or heterociclilo replaced, Said heterociclilo is morfolinilo, piperidinilo, piperazinilo, pirrolidinilo, 2 - [3 - azaespiro oxa - 6.3] HEPTYL, azetidinilo, tiazolidinilo, tiomorfolinilo, dioxotiomorfolinilo oxazepanilo oxa -, 2 -, 6 - azaespiro [3.4] 6 -, Octyl - azaespiro oxa-1 [3.3] HEPTYL, oxa - 2 - 5 - azaespiro [3.4] -, Octyl isoxazolidinilo, AZIRIDINYL, dioxoisotiazolidinilo or oxopirrolidinilo and said heterociclilo replaced is a heterociclilo replaced one to four times elected by substituents with Independence between alkyl, halogen, alkoxy, carboxyl, hydroxyl, hidroxialquilo alkoxyalkyl esters,,, Ciano, alquilamino, dialquilamino, alquilcarbonilamino, alquilcarbonil (alquilamino), phenylAlcoxicarbonilo, aminoalquilo, alquilpirazolilo and alquilisoxazolilo； r u2075 is alkyl, cycloalkyl
