Systems, methods, and computer-readable storage media relate to providing image guidance that can improve the accuracy of interventional procedures, such biopsy sampling, for example, by accurately providing location information to guide the biopsy needle image. The systems, methods, and computer-readable storage media include generating a 3D multi-modality image that includes a pre-procedure reference image and an ultrasound image and displaying at least one view, one of the views including a display in-real-time of a position of the interventional device on the multi-modality image with respect to the target site during the procedure.
