Devices, systems, and methods for visually depicting a vessel of a patient and evaluating treatment potions are disclosed, the method includes introducing a first instrument into the vessel of the patient； introducing a second instrument into the vessel of the patient； moving the second instrument longitudinally through the vessel of the patient from a first position to a second position while maintaining the first instrument in a fixed longitudinal position with respect to the vessel； obtaining pressure measurements from the first and second instruments while the second instrument is moved longitudinally through the vessel； visually depicting the vessel on a display based on the obtained pressure measurements； and modifying the visual depiction of the vessel to simulate one or more treatment options.
