METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION

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专利权人:

发明人:

Kamel KHALILI,Wenhui HU

申请号：

US15885940

公开号：

US20180236045A1

申请日:

2018.02.01

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A method of preventing transmission of a retrovirus from a mother to her offspring, by treating the mothers host cells with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of the proviral DNA, and preventing transmission of the proviral DNA to the offspring.

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中国工程科技知识中心

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http://www.ckcest.cn/home/