Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase

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专利权人:

The Regents of the University of California;Universita Degli Studi Di Urbino “Carlo Bo”;Universita Degli Studi Di Parma

发明人:

Daniele Piomelli,Giorgio Tarzia,Marco Mor,Andrea Duranti,Andrea Tontini

申请号：

US15072194

公开号：

US10363237B2

申请日:

2016.03.16

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases.

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中国工程科技知识中心

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