The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide； an amino ester； an aminoacylanilide； an aminoalkyl benzoate； an amino carbonate； an N-phenylamidine compound； an N-aminoalkyl amid； an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.
