Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.L'invention concerne des méthodes et des compositions pharmaceutiques pour inhiber la 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) et le traitement du cancer.