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ACIDES RIBONUCLÉIQUES BICATÉNAIRES AYANT UNE STRUCTURE PHYSICO-CHIMIQUE ROBUSTE ET UNE ACTIVITÉ BIOLOGIQUE TRÈS SPÉCIFIQUE
专利权人:
HEMISPHERX BIOPHARMA; INC.
发明人:
申请号:
EP09822342.3
公开号:
EP2340307B1
申请日:
2009.10.23
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a selective agonist for activation of the Toll-like receptor 3. Its "rugged" molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation). This structure appears to be responsible for increased efficacy of dsRNA in therapeutic applications and improved biological activity (e.g., used as an immunoregulatory agent). Medicaments, processes for their manufacture, and methods for their use are provided herein.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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