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PHARMACEUTICAL AEROSOL COMPOSITION, INCLUDING AN ANALOGU OF VITAMIN D AND A CORTICOSTEROID
专利权人:
ЛЕО ФАРМА А/С (DK)
发明人:
ЛИН Марианне (DK),РАСМУССЕН Гритт (DK),СОННЕ Метте Рюдаль (DK),ХАНСЕН Йенс (DK),ПЕТЕРССОН Карстен (DK)
申请号:
RU2013100996/15
公开号:
RU2013100996A
申请日:
2011.06.10
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A sprayable, storage-stable, substantially anhydrous topical composition comprising a therapeutically effective amount of a derivative or analogue of vitamin D and a therapeutically effective amount of a corticosteroid, wherein the derivative or analogue of vitamin D and a corticosteroid are dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methyl ethyl ether or a propellant mixture comprising a first propellant selected one of the group consisting of dimethyl ether, diethyl ether and methyl ethyl ether, and a second propellant selected from the group consisting of alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the composition further comprising a pharmaceutically acceptable lipid carrier, dissolved or suspended in the specified propellant or mixture of propellants, and the lipid carrier includes one or more lipids, which when applied to the skin and evaporation of the propellant form semi-solid and occlusal layer at the application site. 2. The composition of claim 1, wherein the derivative or analogue of vitamin D is selected from the group consisting of calcipotriol, calcitriol, tacalcitol, maxacalcitol, paricalcitol and alpha-calcidol. The composition of claim 2, wherein the vitamin D analogue is calcipotriol or calcipotriol monohydrate. The composition according to any one of claims 1 to 3, where the corticosteroid is selected from the group consisting of betamethasone, budenoside, clobetasol, clobetasone, deoxymethasone, diflucortolone, diflorazone, fluocinonide, fluocin1. Распыляемая, стабильная при хранении, по существу, безводная композиция для местного применения, включающая терапевтически эффективное количество производного или аналога витамина D и терапевтически эффективное количество кортикостероида, причем производное или аналог витамина D и кортикостероид растворены в фармацевтически приемлемом пропелленте, выбранном из группы, состо
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http://www.ckcest.cn/home/
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