LEBAN, Johann,BAUMGARTNER, Roland,SAEB, Wael,CHEVRIER, Carine,TASLER, Stefan
申请号：
ES12703013
公开号：
ES2664507T3
申请日:
2012.01.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound of the general formula (I) ** (see formula) ** and pharmaceutically acceptable salts or solvates thereof, wherein R 1 is aryl, heteroaryl, cycloalkyl or alkyl, which may be substituted by one or more R 'Ar substituents it is aryl, cycloalkyl, heterocyclyl or heteroaryl, which may be substituted by one or more R 'substituents； Z is H, halogen, -CR "O, -N (R") 2, -CN, -C (S) R ", -N>； = C (R ') 2, -CO2R", -NR'CO2R " , -CONHR ", -CON (R") 2, -COSR ", -CSNHR", -CSN (R ") 2, -SO2-alkyl, -SO2-haloalkyl, -SO2NHR", -SO2 (NR ") 2 , amino or -SO2R "； Y is H, halogen, haloalkyl, alkyl or an alkyl ester, which may be substituted by one or more substituents R '； R' independently represents H, -CO2R", -CONHR ", -CR" Or, -SO2N (R ") 2, -SO2NHR", -NR "-CO-haloalkyl, -NO2, -NR" -SO2-haloalkyl, -NR "-SO2-alkyl, -SO2-alkyl, -NR" - CO-alkyl, -CN, alkyl, cycloalkyl, aminoalkyl, alkylamino, alkoxy, -OH, -SH, alkylthio, hydroxyalkyl, hydroxyalkylamino, halogen, haloalkyl, haloalkoxy, amino, heterocyclyl, aryl, haloaryl, haloarylalkyl, arylalkyl or heteroaryl； R "independently represents H, haloalkyl, hydroxyalkyl, amino, alkoxy, -N>； = C (R ') 2, -NR'-CO-R', -CR'O, -CO2R ', alkyl, cycloalkyl, aryl, haloaryl , haloarylalkyl, heteroaryl, heterocyclyl, arylalkyl or aminoalkyl, which are optionally substituted by one or more R 'substituents, wherein said "alkyl" comprises alkyl, alkenyl and alkynyl, thus denoting a alkyl group a linear C1-C6 alkyl or branched, preferably a linear or branched chain of one to five carbon atoms； an alkenyl group denotes a linear or branched C2-C6 alkenyl； and an alkynyl group denotes a linear or branched C2-C6 alkynyl group, which may be substituted by one or more substituents R ', wherein the remainder of C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl can be selected from the group consisting of -CH3, -C2H5, - CH>； = CH2, -C≡CH, -C3H7, -CH (CH3) 2, -CH2-CH>； = CH2, -C (CH3)>； = CH2, -CH>； = CH-CH3, -C≡C- CH3, -CH2-C≡CH, -C4H9, -C H2-CH (CH3)
