A non-therapeutic anti-aging skin treatment procedure that extends the effects of botulinum toxin injections over time, the procedure comprising: a. the administration of an effective amount of botulinum toxin to an area of the facial and / or neck skin, b. and the administration, once a week to ten times a day, of a cosmetic composition comprising a cosmetically effective amount of at least one peptide selected from the group consisting of SEQ ID NO: 11, SEQ ID NO: 4 or a sequence of 7 to 12 adjacent amino acids contained in SEQ ID NO: 4, wherein said sequence comprises the amino acid sequence of SEQ ID NO: 11 and according to the general formula (I): R1-AA-R2 (I) its stereoisomers, mixtures and / or cosmetically acceptable salts, in which AA is a sequence selected from the group consisting of SEQ ID NO: 11, SEQ ID NO: 4 or a sequence of 7 to 12 adjacent amino acids contained in SEQ ID NO: 4, wherein said sequence comprises the amino acid sequence of SEQ ID NO: 11, wherein: R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclic, substituted heterocyclyl or unsubstituted, substituted heteroarylalkyl gone or unsubstituted, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5-C (O) -； and R2 is selected from the group consisting of -NR3R4, -OR3 and -SR3； wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl and aralkyl substituted or unsubstituted； wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl and substituted or
