POLY(LACTIC-GLYCOLIC)ACID CROSS LINKED ALENDRONATE (PLGA-ALN) A SHORT TERM CONTROLLED RELEASE SYSTEM FOR STEM CELL DIFFERENTIATION AND DRUG DELIVERY

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专利权人:

Mei-Ling Ho

发明人:

Mei-Ling Ho,Je-Ken Chang,Rajalakshmanan Eswaramoorthy,Shun-Cheng Wu

申请号：

US13446827

公开号：

US20120202064A1

申请日:

2012.04.13

申请国别(地区):

US

年份:

2012

代理人:

摘要：

A short term controlled release composition which comprises poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN) is provided. The PLGA-ALN is constructed into 3D scaffolds (PLGA-ALN-3D) with pores size of 150-300 μm and average porosity of 85%, or microspheres (PLGA-ALN-M) with 50-100 μm in diameter. The released alendronate concentration is in the range of 5×10−7 M to 5×10−8 M.

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中国工程科技知识中心

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http://www.ckcest.cn/home/