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MATRIX OF MICRO-NEEDLES COATED WITH A MEDICINE COMPOSITION
专利权人:
МЕДРЭКС КО., ЛТД. (JP);ТЕЙДЗИН ЛИМИТЕД (JP)
发明人:
ИСИБАСИ Масаки (JP),ХАМАМОТО Хидетоси (JP),ТАНАКА Таиси (JP),КОУНО Кадзутеру (JP),ТОЙОХАРА Кийоцуна (JP)
申请号:
RU2015111197
公开号:
RU2015111197A
申请日:
2013.08.30
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The matrix of microneedles in the form of a nozzle for flowers, in the form of a base with sticking up needles, which is coated with a composition of a medicinal product containing the drug and the additive (s), where the drug composition after loading and drying has a Vickers hardness of 3 or more, and the amount of loaded drug composition is 50-250 μg per 100 microneedles. 2. The microneedle matrix according to claim 1, wherein said Vickers hardness is 10 or more. The microneedle matrix according to claim 1, wherein said Vickers hardness is 12 or greater. The microneedle matrix according to claim 1, wherein said additive is an additive having a Vickers hardness of 10 or more, which acts as an additive giving hardness, or an additive having a Vickers hardness of from 3 to 10.5. The microneedle matrix of claim 1, wherein said additive is a mixture of additives consisting of an additive having a Vickers hardness of 10 or more, which acts as an additive giving hardness, and an additive having a Vickers hardness of 3 to 10.6. The microneedle matrix according to claim 4 or 5, wherein said additive having a Vickers hardness of 3 to 10 is sodium carboxymethyl cellulose. The microneedle matrix of claim 1, wherein said additive is an additive mixture consisting of an additive having a Vickers hardness of less than 3, which acts as an adhesive additive, and an additive having a Vickers hardness of 10 or more, which acts as an additive giving hardness, or a mixture of additives consisting of an additive having a Vickers hardness of less than 3 and an additive having a Vickers hardness of 3 to 10.8. The microneedle matrix according to claim 7, where the specified additive,1. Матрица микроигл в виде насадки для цветов, имеющей форму основания с торчащими вверх иглами, которая покрыта композицией лекарственного средства, содержащей лекарственное средство и добавку (добавки), где композиция лекарственного средства после нагрузки и сушки имеет твердость по Виккерсу 3 или больше
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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