A method of making a multilayer all-ceramic dental appliance. A first article can be formed of a first material based on a first digital surface representation having a desired outer shape of the dental appliance. A portion of the first article can be removed to form an outer layer comprising a cavity dimensioned to accommodate an inner layer. A second article can be formed by filling the cavity of the first article with a second material. The second article can be further processed, as desired. For example, a desired inner shape can be formed in the second article. Such a desired inner shape can be based on a second digital surface representation of a dental object configured to receive the dental appliance. At least one of the first article, the outer layer, and the second article can be fired, for example, while still being coupled to a support.