BRENTJENS, Renier, J.,AVANZI, Mauro, P.,YOO, Sarah
申请号：
EP17837777
公开号：
EP3493827A4
申请日:
2017.08.04
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present disclosure provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to immunoresponsive cells comprising antigen recognizing receptors (e.g., chimeric antigen receptors (CARs) or T cell receptors (TCRs)), and expressing increased level of IL-18. In certain embodiments, the engineered immunoresponsive cells are antigen-directed and resistant to immunosuppression and/or have enhanced immune-activating properties.
