A needle protection device, comprising: a connection portion (2) configured to engage with a needle hub of a needle; a protective arm (6) configured to receive a needle needle tube therein and having a proximal end portion (62) adjacent to the connecting portion (2); a hinge member (4) connected between the connecting portion (2) and the protective arm (6) so that the protective arm (6) can rotate with respect to the connecting portion (2); a pair of clamping members (51, 52) formed in the proximal end portion (62) of the protective arm (6) and the connecting portion (2) respectively, wherein the pair of clamping members (51, 52) they are configured to be coupled with each other when the protection arm (6) rotates in a complete protection position in which the protection arm (6) is closer to the needle needle tube relative to the portion ( 2) of connection, characterized in that the pair of clamping members (51, 52) comprises: a first clamping member (51) comprising a first column-shaped portion (57) and an anchor (55) formed in the first column-shaped portion (57); and a second clamping member (52) comprising one or more legs (53) formed on an edge of a through hole (50) and extending towards a center of the through hole (50), distal ends of the legs or distal ends of the legs and the edge of the through hole (50), defining a hole having a maximum radial dimension of the hole smaller than a maximum radial dimension of an anchor base (55), in which the legs (53) are configured so that the distal ends of the legs allow a leading end of the anchor (55) to pass through the through hole (50) and hold the anchor base (55) in a non-retractable manner when the arm (6) of protection rotates to full protection position.Un dispositivo de protección de aguja, que comprende: una porción (2) de conexión configurada para acoplarse con un cubo de aguja de una aguja; un brazo (6) de protección configurado para recibir un tubo de aguja de la aguja en su interior y que tiene una porc