Peter Leedman,Keith Giles,Michael Epis,Andrew Barker
申请号：
US14383704
公开号：
US20150126581A1
申请日:
2013.03.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3′UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation.
