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吲哚化合物
专利权人:
ASTELLAS PHARMA INC.
发明人:
MATSUMOTO, SHUNICHIRO,松本俊一郎,SHIMIZU, TAKAFUMI,清水乔史,清水喬史,SAITO, TOMOYUKI,斋藤智之,齋藤智之,KANAYAMA, TAKATOSHI,金山俊,TANAKA, HIROAKI,田中宏明,MORI, CHIHARU,森千春,YOKOYAMA, KAZUHIRO,横山和宏,橫山和宏,MATSUI,
申请号:
TW104101079
公开号:
TW201617333A
申请日:
2015.01.13
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
To provide a compound useful as a MT1 and/or MT2 receptor agonist. The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into the central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.本發明為提供一種作為MT1及/或MT2受體激動劑有用之化合物。更詳係為本發明者們對於MT1及/或MT2受體激動劑進行檢討後,確認到吲哚化合物具有該作用而完成本發明。即,本發明之吲哚化合物具有MT1及/或MT2受體激動作用,且中樞移行性低,故作為末梢性MT1及/或MT2受體激動劑可使用於作為尿失禁,特別為腹壓性尿失禁及混合型尿失禁之治療及/或預防劑上。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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