This Hair is bright to be related to the method for Yi Seed System Prepare N- (N'- substituted glycyl base) -2- Cyanopyrolidine,The method includes at least: (a) in the presence of dimethylformamide,The change of formula (V) is set to close the anti-Should of object With L- prolineamide,Wherein mutual Independence on the spot,X1 and X3 Wei Halogen element； X2 Wei Halogen element,OH,O-C (=O)-CH2X3,- O-SO2- (C1-8) alkyl or-O-SO2- (aryl),Sui Hou (b) makes the gained compound not The Fen From With Off water anti-Should of Elixirs,It is non-must Shall Di Sui Hou (c) in the presence of a base,Make the gained compound not The Fen From With Fitness suitable anti-Should of amine,And gained compound (d) is recycled in the form of free form or Suan Jia Cheng Which.本發明涉及一種製備N-(N'-取代甘氨酰基)-2-氰基吡咯烷的方法，該方法包含至少：(a)在二甲基甲酰胺存在下，使式(V)的化合物與L-脯氨酰胺反應，其中相互獨立地，X1和X3爲鹵素；X2爲鹵素、OH、O-C(＝O)-CH2X3、-O-SO2-(C1-8)烷基或-O-SO2-(芳基)，隨後(b)使所得化合物不經分離與脫水劑反應，非必須地隨後(c)在碱存在下，使所得化合物不經分離與適宜的胺反應，以及(d)以自由形式或酸加成鹽的形式回收所得化合物。
