Binding proteins comprising a modified Repeat domain of anquirina polyethylene glycol and a rest of at least 5 kDa Molecular Weight, Pharmaceutical composition comprising such protEINA Union； use of this Protein for treating pathologic angiogenesis.
BINZ, HANS KASPAR,FORRER, PATRICK,STUMPP, MICHAEL TOBIAS,BINZ HANS KASPAR,FORRER PATRICK,STUMPP MICHAEL TOBIAS
申请号：
CL2012003025
公开号：
CL2012003025A1
申请日:
2012.10.29
申请国别(地区):
CL
年份:
2013
代理人:
摘要：
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.PROTEINAS DE UNION MODIFICADA QUE COMPRENDE UN DOMINIO DE REPETICION DE ANQUIRINA Y UN RESTO POLIETILENGLICOL DE 2-100 KDA DE PESO MOLECULAR, QUE UNEN VEGF-A165； USO DE DICHA PROTEINA PARA TRATAR ANGIOGENESIS PATOLOGICA.
