Bayer Pharma Aktiengesellschaft;Bayer Consumer Care AG
发明人:
FREUNDLIEB, Julia,JACOBS, Tia
申请号：
AU2018328812
公开号：
AU2018328812A1
申请日:
2018.09.06
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to : a method of preparing a stable, copanlisib-containing aqueous bulk solution suitable for lyophilisation and for therapeutic applications； a stable, copanlisib-containing bulk solution, of increased solubility which is directly suitable for lyophilisation； a method of lyophilizing such a copanlisib-containing aqueous bulk solution； a stable, lyophilized, copanlisib-containing solid, in particular powder or cake, particularly containing a therapeutic dose of copanlisib in one or two containers, particularly one sealed container； a method of reconstituting such lyophilisates； and a stable, reconstituted, copanlisib-containing solution of increased solubility, suitable for further dilution and for therapeutic applications.
