The present disclosure relates to a pharmaceutical composition of CD40 antibody and use thereof. Specifically, the pharmaceutical composition of CD40 antibody of the present disclosure comprises an anti-CD40 antibody or an antigen-binding fragment thereof in an acetate-sodium acetate buffer. In addition, the pharmaceutical composition may further comprise sugars, non-ionic surfactants and other excipients. The pharmaceutical composition of the present disclosure exhibits good antibody stability after several months of storage.本公開涉及一種CD40抗體藥物組合物及其用途。具體而言,本公開涉及的CD40抗體藥物組合物其包含在醋酸-醋酸鈉緩衝液中的CD40抗體或其抗原結合片段。除此之外,該藥物組合物還可含有糖、非離子型表面活性劑和其他輔料。本公開藥物組合物在儲存數月之後展現了良好的抗體穩定性。