A tissue disruption device may comprise a deflectable elongated tissue disrupting element rotatable around its central axis, the central axis being a longitudinal axis when the disrupting element is in a straightened state. The tissue disrupting element may be rotatably anchored at a distal location and may be deflectable into a curved configuration. A rotary drive configured to rotate the tissue disrupting element around its central axis in the straightened state and in the curved configuration. An elongated element may be wound around and rigidly affixed to the tissue disrupting element. In some embodiments, the elongated element protrudes sufficiently radially from the tissue disrupting element that rotation of the tissue disrupting element generates an axial motion of disrupted tissue. In one preferred embodiment, the tissue disrupting element and/or elongated element comprises wire mesh.
