The present invention provides a compound useful as an agent for the prevention or treatment of a sex hormone-dependent disease or the like. That is, the present invention provides a fused heterocyclic derivative represented by the following general formula (I), a pharmaceutical composition containing the same, a medicinal use thereof and the like. In the formula (I), ring A represents 5-membered cyclic unsaturated hydrocarbon or 5-membered heteroaryl； R A represents halogen, alkyl, alkenyl, alkynyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like； ring B represents aryl or heteroaryl； R B represents halogen, alkyl, carboxy, alkoxy, carbamoyl, alkylcarbamoyl or the like； E 1 and E 2 represent an oxygen atom or the like； U represents a single bond or alkylene； X represents a group represented by Y, -SO 2 -Y, -O-(alkylene)-Y, -O-Z in which Y represents Z, amino or the like； Z represents cycloalkyl, heterocycloalkyl, aryl, heteroaryl or the like； or the like.
