OTTO, Christiane,WOLF, Siegmund,FREIBERG, Christoph,HARRENGA, Axel,GREVEN, Simone,TRAUTWEIN, Mark,BRUDER, Sandra,EICKER, Andrea,WILMEN, Andreas
申请号：
DK10782255
公开号：
DK2510006T3
申请日:
2010.11.18
申请国别(地区):
DK
年份:
2017
代理人:
摘要：
The present invention is directed to neutralizing prolactin receptor antibodies and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling.
