The objective of the present invention is to discover an effective cancer treatment method and to provide a medicine. The present invention provides a medicine comprising the combinations of a compound represented by the general formula (I), a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof and an immune checkpoint inhibitor (for example, anti-PD-I).The combination of the present invention exerts strong antitumor effect and is therefore useful for treating cancer.本發明之課題為發現有效之癌治療法，而提供醫藥品。本發明提供將通式(I)表示之化合物、其鹽、其溶劑化物、其N-氧化物或這些化合物之前藥與免疫核查點阻礙藥(例如抗PD-1抗體等)組合而成之醫藥本發明之組合由於發揮強力抗腫瘍效果，對癌治療有用。
