This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.본 발명은 합성 나노운반체로부터 시차를 두고 방출되는 면역조절제 및 항원을 포함하는 합성 나노운반체의 조성물 및 관련 방법에 관한 것이다.