NOVEL EXPRESSION VECTORS CONTAINING ACCESSORY MOLECULE LIGAND GENES AND THEIR USE FOR IMMUNOMODULATION AND TREATMENT OF MALIGNANCIES AND AUTOIMMUNE DISEASE

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专利权人:

UNIVERSITY OF CALIFORNIA

发明人:

KIPPS, THOMAS J.,SHARMA, SANJAI,CANTWELL, MARK

申请号：

CA2707726

公开号：

CA2707726C

申请日:

1997.12.08

申请国别(地区):

CA

年份:

2013

代理人:

摘要：

This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the molecules of this invention are also discussed.

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