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Hemiasterlin derivatives for conjugation and therapy
专利权人:
Sutro Biopharma; Inc.
发明人:
Kline, Toni,Yin, Qun,Bajjuri, Krishna
申请号:
AU2016211165
公开号:
AU2016211165A1
申请日:
2016.01.29
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
Provided herein are hemiasterlin derivatives, conjugates thereof, compositions comprising the derivatives or conjugates thereof, methods of producing the derivatives and conjugates thereof, and methods of using the derivatives, conjugates, and compositions for the treatment of cell proliferation. The derivatives, conjugates, and compositions are useful in methods of treatment and prevention of cell proliferation and cancer, methods of detection of cell proliferation and cancer, and methods of diagnosis of cell proliferation and cancer. In an embodiment, the hemiasterlin derivatives are according to Formula 1000: or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein Ar, L, W
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