Jong Yeon HWANG,Jae Du HA,Sung Yun CHO,Pil Ho KIM,Chang Soo YUN,Chi Hoon PARK,Chong Ock LEE,Sang Un CHOI,Joo Youn LEE,Sunjoo AHN
申请号：
US16609805
公开号：
US20200062730A1
申请日:
2018.05.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.
