Macdonald, Lynn,McWhirter, John,Gurer, Cagan,Meagher, Karolina,Murphy, Andrew J.
申请号：
AU2018203811
公开号：
AU2018203811A1
申请日:
2018.05.30
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018203811A120180621.pdf#####ABSTRACT Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments. Methods for making antibody sequences that bind an antigen (e.g., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human VH gene segment, a plurality of human DH gene segments and a plurality of JH gene segments, at the endogenous immunoglobulin heavy chain locus.
