Provided is a multi-arm polyethylene glycol-azido derivative of general formula I, wherein R is a central molecule, which is selected from a polyhydroxy structure, a polyamino structure or a polycarboxyl structure； n is the number of branches or arms, n‰§3； PEG is the same or different -(CH 2 CH 2 O) m -, the average value of m being an integer from 3 to 250； X is a linking group of an azido end group； k is the number of the branches having the azido end group； F is selected from the group consisting of amino, carboxyl, sulfhydryl, ester group, maleic imide group and acrylic group； and Y is a linking group of an end group F.
