Temple University- Of the Commonwealth System of Higher Education
发明人:
Azadeh Timnak,Jonathan A. Gerstenhaber,Yah-el H. Har-el,Peter I. Lelkes
申请号：
US16339955
公开号：
US20200038248A1
申请日:
2017.10.05
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides methods for improving negative pressure wound therapy. The application of negative pressure to a wound bed with a biodegradable biocompatible fibrous scaffold facilitates cell infiltration into the scaffold serving as a 3D structure, as opposed to solely application of the scaffold without any pressure, which shows minimal cell penetration. In vitro studies show that infiltration of immune cells into scaffolds paves the way for their polarization towards the phenotype pertinent to the remodeling stage 2. The cell penetration factor causes less intense immune response of the host body, leading the inflammation to proceed to the remodeling stage.
