DAVID LONARD,BERT W. OMALLEY,JOHN NEMUNAITIS,DONALD RAO
申请号：
ARP150101261
公开号：
AR101440A1
申请日:
2015.04.27
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Requirement 1: rnhp with dual functions can reduce the expression of three or more genes, which is characterized by: the first dual function RNA molecule, reducing the expression of the first white gene； the second dual function RNA molecule, reducing the expression of the second white gene； the third molecule In this case, each RNA molecule can activate a silencing complex driven by RNA to cut independently, so as to reduce the expression level of RNA, which is an independent cutting machine,The second and third white genes 19. Claim 6: rnhp and claim 1 have dual functions, which is characterized in that at least one, two or three molecules of RN dual functions are selected from SEQ ID 5-22, SEQ ID 23-32, SEQ ID 33-34, SEQ ID 36-37, SEQ ID 38-39 or SEQ ID 44-45. Claim 9: an expression vector, which is characterized in that it comprises: a salesman； a nucleic acid insertion device operatively connected with the salesman, comprising: the first dual-function molecule of RNA, reducing the expression of the first white gene；The second bifunctional RNA molecule reduces the expression of the second white gene； the third bifunctional RNA molecule reduces the expression of the third white gene, wherein the bifunctional RNA molecule can activate a RNA induced silencing complex that depends on tailoring and independent tailoring to reduce The expression level of the first, second and third white genes, in which one or more rnhp is composed of a dual-function RNA molecule, which activates a RNA driven silencing integrated device and reduces the expression level of RNA by cutting and independent cutting,The second and third white genes Claim 15: a treatment management system, which is characterized by: a treatment agent vehicle； an expression vector including a nucleic acid promoter and an insertion agent with business relationship with the promoter, Where nucleic acids are encoded: the first dual-function RNA molecule reduces the expression of the first white gene； the second
