A stethoscope protective cover for shielding a stethoscope head. The stethoscope protective cover is a sleeve with an open end and a closed end configured to fit closely around the diaphragm or bell of a stethoscope chest piece. The sleeve is made from an acoustically transmissive material, ensuring that the acoustical vibrations from a patient's body are minimally affected when the sleeve covers the chest piece. A first fastener and second fastener are placed toward the open end of the sleeve, with a slot between them that allows for the tubing of a stethoscope to extend therethrough. A tab is placed near the open end of the stethoscope protective cover to facilitate opening the sleeve and placing the stethoscope chest piece therein.