AVACYN PHARMACEUTICALS, INC;THE ROCKEFELLER UNIVERSITY
发明人:
ALLAN R. GOLDBERG,RAYMOND SCHUCH,VINCENT A. FISCHETTI
申请号：
BR112015002846
公开号：
BR112015002846A2
申请日:
2013.08.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The application describes targets and methods that can inhibit bacterial growth in Gram-positive and Gram-negative bacteria. A bacterial enzyme, 2-epimerase, is common to both Gram-positive and Gram-negative bacteria and contains an allosteric site that can be targeted to disrupt the enzyme. The allosteric site is present on the bacterial 2-epimerase, but the analogous mammalian enzyme does not contain the allosteric site, providing a route for attacking bacterial infections without affecting the mammalian enzyme.
