The present invention relates to κ opioid receptor agonist in the preparation of a medicament for the treatment of pruritus induced by farnesoid x receptor agonist. The present invention also relates to combination use of farnesoid x receptor agonist and κ opioid receptor agonist in the preparation of a medicament for the treatment of portal hypertension, cholestatic liver diseases, primary biliary cirrhosis, bile acid diarrhea or nonalcoholic fatty liver disease.本發明涉及一種κ類鴉片受體激動劑在製備治療法尼醇X受體激動劑引起的瘙癢的藥物中的用途。本發明還涉及一種法尼醇X受體激動劑聯合κ類鴉片受體激動劑在製備治療門靜脈高壓、膽汁淤積性肝病、原發性膽汁性肝硬化、膽汁酸腹瀉或非酒精性脂肪肝的藥物中的用途。無,因為實驗數據。
