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3-fenylpyrazol derivater, farmasøytiske sammensetninger inneholdende slike, fremgangsmåte for fremstilling og anvendelse som modulatorer av 5HT2A serotoninreseptoren for behandling av forstyrrelser relatert dertil
专利权人:
Arena Pharmaceuticals Inc
发明人:
Jones, Robert M,Choi, Jin Sun Karoline,Xiong, Yifeng,Casper, Martin,Lehmann, Juerg,Teegarden, Bradley,Jayakumar, Honnappa,Strah-Pleynet, Sonja,Dosa, Peter I,Feichtinger, Konrad,Unett, David J
申请号:
NO20072986
公开号:
NO340656B1
申请日:
2007.06.11
申请国别(地区):
NO
年份:
2017
代理人:
摘要:
The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula ( Ia ) and pharmaceutical compositions thereof that modulate the activity of the 5-HT 2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourettes syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT 2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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