587202 Disclosed is the use of (a) an analgesic potentiating compound and (b) an analgesic compound in the manufacture of a medicament to treat pain by potentiating the analgesic properties of said analgesic compound, wherein (i) the analgesic compound is an analgesic effective amount of a compound selected from the group consisting of ibuprofen, or the pharmaceutically acceptable salt or isomer thereof, at a dosage from 100 mg to 800 mg of the composition, and (ii) the analgesic potentiating compound is a compound selected from the group consisting of nizatidine, or the pharmaceutically effective salt or isomer thereof at a dosage from 10 mg to 200 mg of the composition, and wherein the medicament is formulated for separate, sequential or simultaneous administration of (a) and (b).