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PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE
专利权人:
Yasuhiro Goto
发明人:
Yasuhiro Goto,Kenji Niyama,Satoshi Sunami,Keiji Takahashi
申请号:
US13202773
公开号:
US20120134955A1
申请日:
2010.02.18
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a): R1 means a —(C═O)aOb(C1-C6)alkyl group, a —(C═O)aOb(C2-C6)alkenyl group, a —(C═O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a —(C═O)aOb(C1-C6)alkyl group or a group of —(C═O)aN(R1e)R2e R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee 1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.
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