The present invention relates to antibodies that specifically bind to TIGIT (T cell immunoreceptor with Ig and ITIM domains, WUCAM or Vstm3) and inhibit Tigit-mediated cellular signaling and activities in immune cells. The present invention also includes the uses of these antibodies to treat or diagnose cancer, infectious diseases or other pathological disorders that may be modulated by Tigit-mediated functions.本發明涉及抗體，該抗體與TIGIT（具有Ig和ITIM結構域的T細胞免疫受體，WUCAM或Vstm3）特異性地結合並抑制免疫細胞中的Tigit介導的細胞信號傳導和活性。本發明還包括這些抗體用於治療或診斷可以被Tigit介導的功能調節的癌症、感染性疾病或其他病理性失調的用途。
